{"id":10016,"date":"2020-09-04T11:25:16","date_gmt":"2020-09-04T01:25:16","guid":{"rendered":"http:\/\/arthritisaustralia.com.au\/?page_id=10016"},"modified":"2020-09-11T15:10:23","modified_gmt":"2020-09-11T05:10:23","slug":"dr-ming-chin-lee","status":"publish","type":"page","link":"https:\/\/old.arthritisaustralia.org.au\/wordpress\/dr-ming-chin-lee\/","title":{"rendered":"Dr Ming- Chin Lee"},"content":{"rendered":"<table>\n<tbody>\n<tr>\n<td width=\"161\">Funded by:<\/td>\n<td width=\"470\">Jointly funded by Arthritis Australia and Arthritis Western Australia<\/td>\n<\/tr>\n<tr>\n<td width=\"161\">Recipient:<\/td>\n<td width=\"470\">Dr Ming- Chin Lee<\/td>\n<\/tr>\n<tr>\n<td width=\"161\">Intended Department<\/td>\n<td width=\"470\">Department of Medicine (RMH) University Of Melbourne<\/td>\n<\/tr>\n<tr>\n<td width=\"161\">Project:<\/td>\n<td width=\"470\"><em>CCL 17 in osteoarthritis and its associated pain<\/em><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p>My ongoing research program is to focus on two main goals (i) understanding the role(s) of inflammatory cytokines\/chemokines in musculoskeletal (MSK) conditions, including inflammatory arthritis and osteoarthritis (OA) and (ii) defining and validating new therapeutic targets for these diseases.<\/p>\n<p>My early study discovered a new pathway where the chemokine CCL17 is an effector molecule of GM-CSF (granulocyte macrophage-colony stimulating factor) and induces via a transcriptional factor, interferon regulatory factor 4 (IRF4), which is essential for inflammatory and arthritic pain and disease development in experimental animal models. I have also validated CCL17 as a potential therapeutic target using a therapeutic antibody-based protocol. This body of work has been published in a top ranking clinical journal, <em>Journal of Clinical Investigation<\/em>. I also found that TNF (tumour necrosis factor) is only required at the early stage of disease development (<em>published in<\/em> <em>Journal of Clinical Investigation Insight<\/em>). This finding acts as a knowledge foundation warranting future research in other MSK conditions, where pain is relevant. As such, using an experimental model of OA, I have determined the importance of CCL17 in OA pain development and validated it as a potential therapeutic target by using a monoclonal antibody-based therapeutic protocol neutralizing CCL17 in the OA model. This is the <strong>first<\/strong> time CCL17 has been proposed as a potential therapeutic target for OA and was recently published in <em>Arthritis Research &amp; Therapy<\/em>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Project: CCL 17 in osteoarthritis and its associated pain<br \/>\nFunded by: Jointly funded by Arthritis Australia and Arthritis Western Australia<br \/>\nIntended Department Department of Medicine (RMH) University Of Melbourne <\/p>\n","protected":false},"author":84,"featured_media":10077,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"class_list":["post-10016","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/old.arthritisaustralia.org.au\/wordpress\/wp-json\/wp\/v2\/pages\/10016","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/old.arthritisaustralia.org.au\/wordpress\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/old.arthritisaustralia.org.au\/wordpress\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/old.arthritisaustralia.org.au\/wordpress\/wp-json\/wp\/v2\/users\/84"}],"replies":[{"embeddable":true,"href":"https:\/\/old.arthritisaustralia.org.au\/wordpress\/wp-json\/wp\/v2\/comments?post=10016"}],"version-history":[{"count":0,"href":"https:\/\/old.arthritisaustralia.org.au\/wordpress\/wp-json\/wp\/v2\/pages\/10016\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/old.arthritisaustralia.org.au\/wordpress\/wp-json\/wp\/v2\/media\/10077"}],"wp:attachment":[{"href":"https:\/\/old.arthritisaustralia.org.au\/wordpress\/wp-json\/wp\/v2\/media?parent=10016"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}